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MYP_036946
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Basic Information
Insulin-like growth factor I
Binding / Molecular interaction ▸ Binding activity
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Cytokine modulation
Metabolic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Tissue repair / Regeneration ▸ Bone regeneration
Standard
70 amino acids
C331H518N94O101S7
Standard
Sequence
GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
Physicochemical Analysis
7654.68 Da
7.76
0.71
0.40
0.0101
-0.27
0.46
-0.05
67.24
60.00
0.1000
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3126.93
-34.81
115.0
109.0
246.0
533.0
12.0
72.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0389911 VERIFIED: YES
Provenance & Taxonomy
Equus caballus [Animal]
Insulin-like growth factor
9796
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling
Experimental: 0.033±0.004 (t1/2 α) hours; /118.8 seconds; Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Insulin-like growth factor I (Equus caballus): PMID 8860303##11145579 PMID8860303;11145579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8860303/
RECORD: Rec_0393718 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
IGF
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
I125 labeling
Bio-Activity Profile
Endocrine
Receptor-precipitable radioactivity
Rat Duodenum luminal flushing, in vitro; 120 s
PaperDegradation of IGF-I in the adult rat gastrointestinal tract is limited by a specific antiserum or the dietary protein casein PMID7561632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7561632/
RECORD: Rec_0398732 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
IGF
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
I125 labeling
Bio-Activity Profile
Endocrine
Antibody assay
Rat Duodenum luminal flushing, in vitro; 120 s
PaperDegradation of IGF-I in the adult rat gastrointestinal tract is limited by a specific antiserum or the dietary protein casein PMID7561632 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7561632/
RECORD: Rec_0402878 VERIFIED: YES
Provenance & Taxonomy
Canis lupus familiaris [Animal]
Insulin-like growth factor
9615
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
Experimental: 0.033±0.004 (t1/2 α) hours; /118.8 seconds; Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Insulin-like growth factor I (Canis lupus familiaris): PMID 8359700##11145579 PMID8359700;11145579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8359700/
RECORD: Rec_0406469 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Insulin-like growth factor
9913
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-48; 18-61; 47-52
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation
Experimental: 0.033±0.004 (t1/2 α) hours; /118.8 seconds; Mammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour
PaperBinding protein-3-selective insulin-like growth factor I variants: engineering, biodistributions, and clearance PMID11145579 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11145579/
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