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MYP_036915
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Basic Information
Spheniscin-2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
38 amino acids
C194H314N70O43S6
Standard
Sequence
SFGLCRLRRGFCARGRCRFPSIPIGRCSRFVQCCRRVW
Physicochemical Analysis
4507.40 Da
11.63
9.40
9.11
0.2474
-0.09
0.78
-0.25
52.95
58.95
0.1316
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1861.01
-19.46
78.0
59.0
145.0
313.0
8.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0197875 VERIFIED: YES
Provenance & Taxonomy
Aptenodytes patagonicus [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-33, 12-27, 17-34
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus aureus
1.5-3 μM
MIC
PMID14525994;15123713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14525994/
RECORD: Rec_0205209 VERIFIED: YES
Provenance & Taxonomy
Aptenodytes patagonicus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli 1106
1.5-3.0 μM
MIC
PMID14525994;15123713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14525994/
RECORD: Rec_0224464 VERIFIED: YES
Provenance & Taxonomy
Aptenodytes patagonicus [Animal]
beta-defensin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
5-33; 12-27; 17-34
Bio-Activity Profile
Antimicrobial beta-defensin family Antibacterial Antifungal Host defense Defensin-like
PaperPDB 1UT3 structural record; NMR; chain A; residues 1-38
RECORD: Rec_0237660 VERIFIED: YES
Provenance & Taxonomy
Aptenodytes patagonicus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0239546 VERIFIED: YES
Provenance & Taxonomy
Aptenodytes patagonicus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus
1.5-3.0 μM
MIC
PMID14525994;15123713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14525994/
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