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MYP_036915
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Basic Information
Spheniscin-2
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
38 amino acids
C194H314N70O43S6
Standard
Sequence
SFGLCRLRRGFCARGRCRFPSIPIGRCSRFVQCCRRVW
Physicochemical Analysis
4507.40 Da
11.63
9.40
9.11
0.2474
-0.09
0.78
-0.25
52.95
58.95
0.1316
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1861.01
-19.46
78.0
59.0
145.0
313.0
8.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0011289 VERIFIED: YES
Provenance & Taxonomy
Aptenodytes patagonicus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
V. metshnikovii NCTC 8483
25-50 μM
MIC
PMID14525994;15123713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14525994/
RECORD: Rec_0014041 VERIFIED: YES
Provenance & Taxonomy
Aptenodytes patagonicus [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-33, 12-27, 17-34
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Vibrio metschnikovii NCTC 8483
25-50 μM
MIC
PMID14525994;15123713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14525994/
RECORD: Rec_0015875 VERIFIED: YES
Provenance & Taxonomy
Aptenodytes patagonicus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Bacillus cereus ATCC 11778
3-6 μM
MIC
PMID14525994;15123713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14525994/
RECORD: Rec_0016398 VERIFIED: YES
Provenance & Taxonomy
Aptenodytes patagonicus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://patents.google.com/patent/US7384911B2/en PatentUS 7384911 B2
RECORD: Rec_0026085 VERIFIED: YES
Provenance & Taxonomy
Aptenodytes patagonicus [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-33, 12-27, 17-34
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus haemolyticus
1.5-3 μM
MIC
PMID14525994;15123713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14525994/
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