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MYP_036868
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Basic Information
Temporin B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C83H121N19O16
Standard
Sequence
FVQWFSKFLGRIL
Physicochemical Analysis
1640.97 Da
11.00
1.76
1.55
0.1353
0.82
0.70
0.34
24.05
112.31
0.3077
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
579.55
-0.26
21.0
18.0
52.0
118.0
5.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0123383 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Plant]
Temporin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiparasitic Anticancer
No MICs found in DRAMP database
PMID9022710 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9022710/
RECORD: Rec_0128582 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Frog skin active peptide
8407
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Leucine amide at position 13 reported in entry
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiparasitic Anticancer
Mammalian 1.1 h; Yeast 3 min; E. coli 2 min
PaperTemporins, antimicrobial peptides from the European red frog Rana temporaria PMID9022710 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9022710/
RECORD: Rec_0141018 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Defense peptide Antimicrobial Antibiotic Antiparasitic Anti-Gram-negative Anti-Gram-positive Cytolytic Anticancer Cytotoxic Hemolytic
Gram Negative Bacteria and Gram Positive Bacteria
PMID9022710;34235566;12133008;16801429;16867990;25668079;18370376;21586570;31358802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9022710/
RECORD: Rec_0146957 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
8407.0
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
6 μM
Hemolysis
PaperMangoni ML, Carotenuto A, Auriemma L, et al. Structure-activity relationship, conformational and biological studies of temporin L analogues. J Med Chem. 2011 Mar 10;54(5):1298-1307. doi:10.1021/jm1012853. PMID21319749 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21319749/
RECORD: Rec_0151635 VERIFIED: YES
Provenance & Taxonomy
Rana temporaria [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
E.coli
PMID9022710 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9022710/
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