Peptide Database

Peptide NameSLAY-screened peptide P2796

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC114H184N32O29S

DescriptionStandard

        TLKCQRYQFVQIRKLSNPYI
    

Molecular Weight2498.94 Da

Isoelectric Point (pI)10.03

Net Charge (pH 7.0)3.38

Net Charge (pH 7.4) 3.17

Charge Density (pH 7.0) 0.1692

GRAVY Index-0.52

Hydrophobic Moment 0.42

Boman Index-0.18

Instability Index-11.74

Aliphatic Index 92.50

Aromaticity 0.1500

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1036.55

LogP -8.15

H-bond Donors 37.0

H-bond Acceptors 34.0

Rotatable Bonds 83.0

Heavy Atoms 176.0

Ring Count 4.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0021931 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/