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MYP_036804
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Basic Information
VIRIP[K3,p10,L-Tic13]
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
not Standard
20 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
LEKIPMSIPPEVXFNKPFVF
Physicochemical Analysis
0.00 Da
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0016097 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
VIRIP-derived peptide
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
The 'X' at position 13 is L-tetrahydro-isoquinoline-3-carboxylic acid(Tic).
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1
0.41±0.13 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide. | Münch J, Ständker L, Adermann K, Schulz A, Schindler M, Chinnadurai R, Pöhlmann S, Chaipan C, Biet T, Peters T, Meyer B, Wilhelm D, Lu H, Jing W, Jiang S, Forssmann WG, Kirchhoff F. | Cell. 2007 Apr 20;129(2):263-75. | DOI:10.1016/j.cell.2007.02.042 | PMID:17448989 PMID17448989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17448989/
RECORD: Rec_0188322 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
The 'X' at position 13 is L-tetrahydro-isoquinoline-3-carboxylic acid(Tic)
Bio-Activity Profile
Antimicrobial Antiviral
PaperDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide PMID17448989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17448989/
RECORD: Rec_0205031 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
The 'X' at position 13 is L-tetrahydro-isoquinoline-3-carboxylic acid(Tic)
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of virus infection in P4-CCR5 cells
0.41±0.13 μM
IC50
PaperDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide PMID17448989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17448989/