Peptide Database

Peptide NameSLAY-screened peptide P1854

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC114H157N25O25S

DescriptionStandard

        YTPFHSFPIWPCPPSLHLAV
    

Molecular Weight2309.68 Da

Isoelectric Point (pI)6.91

Net Charge (pH 7.0)-0.08

Net Charge (pH 7.4) -0.40

Charge Density (pH 7.0) -0.0038

GRAVY Index0.36

Hydrophobic Moment 0.13

Boman Index0.42

Instability Index49.63

Aliphatic Index 78.00

Aromaticity 0.2000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 726.34

LogP -1.66

H-bond Donors 24.0

H-bond Acceptors 28.0

Rotatable Bonds 57.0

Heavy Atoms 165.0

Ring Count 12.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0138143 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/