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MYP_036688
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ Glutamate carboxypeptidase II inhibition ▸ Glutamate carboxypeptidase II inhibitor
Hormonal / Endocrine ▸ Hormone peptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
2 amino acids
C13H16N2O5
Standard
Sequence
DF
Physicochemical Analysis
280.28 Da
4.05
-1.24
-1.44
-0.6194
-0.35
0.81
0.14
-32.70
0.00
0.5000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
129.72
-0.40
4.0
4.0
7.0
20.0
1.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0268340 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
363.1 μM
IC50
PaperWu J., Aluko R. E., Nakai S.. Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006.
RECORD: Rec_0285373 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
20000 μM
IC50
PaperStructural requirements of Angiotensin I-converting enzyme inhibitory peptides: quantitative structure-activity relationship study of di- and tripeptides. PMID16448176 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16448176/
RECORD: Rec_0376273 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Glutamate Carboxypeptidase Ii Inhibitor
Glutamate carboxypeptidase II
PaperRobinson M. B., Blakely R. D., Couto R., Coyle J. T. Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. J. Biol. Chem., 262, 14498-14506, 1987. PMID3667587 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3667587/
RECORD: Rec_0378024 VERIFIED: YES
Provenance & Taxonomy
Engraulis japonicus [Animal]
Angiotensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory ACE inhibitory
Angiotensin-converting enzyme
360 μM
IC50
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