Peptide Database

Peptide NameVpr 53-67

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC79H131N21O21

DescriptionStandard

        TWAGVEAIIRILQQL
    

Molecular Weight1711.01 Da

Isoelectric Point (pI)5.66

Net Charge (pH 7.0)-0.60

Net Charge (pH 7.4) -0.79

Charge Density (pH 7.0) -0.0399

GRAVY Index0.79

Hydrophobic Moment 0.76

Boman Index0.32

Instability Index36.71

Aliphatic Index 162.67

Aromaticity 0.0667

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 692.12

LogP -3.49

H-bond Donors 24.0

H-bond Acceptors 21.0

Rotatable Bonds 56.0

Heavy Atoms 121.0

Ring Count 2.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0413546 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

Targetinhibition of disintegration catalyzed by integrase

Activity27 μM

MethodIC50

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