‹ ›
MYP_036667
← PREVIOUS NEXT → BACK
Basic Information
Vpr 53-67
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition
Standard
15 amino acids
C79H131N21O21
Standard
Sequence
TWAGVEAIIRILQQL
Physicochemical Analysis
1711.01 Da
5.66
-0.60
-0.79
-0.0399
0.79
0.76
0.32
36.71
162.67
0.0667
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
692.12
-3.49
24.0
21.0
56.0
121.0
2.0
16.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0012286 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of strand transfer catalyzed by integrase
144 μM
IC50
PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
RECORD: Rec_0052252 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV Replication inhibition
HIV
200 μM
IC50
Mammalian: 7.2 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of the activities of reverse transcriptase and integrase of human immunodeficiency virus type-1 by peptides derived from the homologous viral protein R (Vpr). | Gleenberg IO, Herschhorn A, Hizi A. | J Mol Biol. 2007 Jun 22;369(5):1230-43. | DOI:10.1016/j.jmb.2007.03.073 | PMID:17490682 PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
RECORD: Rec_0084744 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Replication inhibition
inhibit the activity of Rnase H
6.9 μM
IC50
Mammalian: 7.2 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of the activities of reverse transcriptase and integrase of human immunodeficiency virus type-1 by peptides derived from the homologous viral protein R (Vpr). | Gleenberg IO, Herschhorn A, Hizi A. | J Mol Biol. 2007 Jun 22;369(5):1230-43. | DOI:10.1016/j.jmb.2007.03.073 | PMID:17490682 PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
RECORD: Rec_0113155 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Inhibition of 3′-end processing catalyzed by integrase
200 μM
IC50
PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
RECORD: Rec_0119329 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
1 2 3 4 NEXT LAST
Showing 5 records on this page · Page 1 of 4