Peptide Database

Peptide NameAdrenomedullin

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Hormonal / Endocrine ▸ Hormone peptide

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length52 amino acids

Chemical FormulaC259H394N78O78S3

DescriptionStandard

        YRQSMNNFQGPRSFGCRFGTCTVQKLAHQIYQFTDNDKDGVAPRSKISPQGY
    

Molecular Weight5944.57 Da

Isoelectric Point (pI)9.51

Net Charge (pH 7.0)3.82

Net Charge (pH 7.4) 3.53

Charge Density (pH 7.0) 0.0736

GRAVY Index-0.92

Hydrophobic Moment 0.64

Boman Index-0.18

Instability Index40.70

Aliphatic Index 37.50

Aromaticity 0.1346

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4595.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2577.40

LogP -32.12

H-bond Donors 90.0

H-bond Acceptors 86.0

Rotatable Bonds 194.0

Heavy Atoms 418.0

Ring Count 11.0

Amide Bonds 60.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0147212 VERIFIED: YES

Provenance & Taxonomy

OrganismCanis lupus familiaris [Animal]

FamilyAdrenomedullin

Tax ID9615

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide16-21

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Receptor modulation

Half-LifeMammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min