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MYP_036564
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Basic Information
Temporin-SHf
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
8 amino acids
C57H77N11O10
Standard
Sequence
FFFLSRIF
Physicochemical Analysis
1076.29 Da
9.75
0.76
0.56
0.0950
1.77
0.55
0.56
32.83
97.50
0.5000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
349.15
1.11
13.0
11.0
32.0
78.0
4.0
7.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000044 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharicus [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
MIC 25 uM; but not Escherichia coli K12
>100 μM
MIC
PaperTemporin-SHf, a new type of phe-rich and hydrophobic ultrashort antimicrobial peptide
RECORD: Rec_0001431 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharicus [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Aspergillus flavus
200 μM
MIC
PMID20308076 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20308076/
RECORD: Rec_0001896 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharica [Animal]
Temporin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes
200 μM
LC50
PMID20308076 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20308076/
RECORD: Rec_0009702 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharicus [Animal]
Temporin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
12.5 μM
MIC
PaperF. Abbassi et al. / The Journal of Biological Chemistry 285 (2010) 16880-16892. Temporin-SHf, a New Type of Phe-rich and Hydrophobic Ultrashort Antimicrobial Peptide Evidence URLhttps://www.uniprot.org/uniprotkb/D4YWD1/entry
RECORD: Rec_0010786 VERIFIED: YES
Provenance & Taxonomy
Pelophylax saharica. [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
100 μM
MIC
PMID28105725 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28105725/
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