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MYP_036457
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Basic Information
Lfcin B (19-25)-C
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
8 amino acids
C51H76N20O10S2
Standard
Sequence
CRRWQWRC
Physicochemical Analysis
1193.41 Da
10.41
2.74
2.51
0.3425
-1.73
0.47
-0.78
151.95
0.00
0.2500
11000.00
11125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
527.39
-3.85
23.0
15.0
36.0
83.0
4.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0338729 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferricin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
1-8
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
3.8 μM
LD99
Human Serum: Have half-lifes of ~1.5 h
PaperNguyen LT, Chau JK, Perry NA, de Boer L, Zaat SA, Vogel HJ. Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. PLoS One. 2010 Sep 10;5(9):e12684. PMID:20844765 https://pubmed.ncbi.nlm.nih.gov/20844765/ PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0344306 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
Hemolysis
PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0345187 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus 42D
60 μM
LC
PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0351753 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ML-35
15 μM
LC
PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
RECORD: Rec_0356375 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
-
Amidation
1-8
Bio-Activity Profile
Antimicrobial Anti-Gram-positive
Staphylococcus aureus
3.8 μM
LD99.99
Human serum, in vitro; ~5400 s
PaperSerum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs PMID20844765 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20844765/
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