Peptide Database

Peptide NameCathelicidin-4 (Indolicidin)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length144 amino acids

Chemical FormulaC737H1160N204O215S5

DescriptionStandard

        MQTQRASLSLGRWSLWLLLLGLVVPSASAQALSYREAVLRAVDQLNELSSEANLYRLLELDPPPKDNEDLGTRKPVSFTVKETVCPRTIQQPAEQCDFKEKGRVKQCVGTVTLDPSNDQFDLNCNELQSVILPWKWPWWPWRRG
    

Molecular Weight16478.66 Da

Isoelectric Point (pI)6.29

Net Charge (pH 7.0)-0.51

Net Charge (pH 7.4) -0.82

Charge Density (pH 7.0) -0.0036

GRAVY Index-0.42

Hydrophobic Moment 0.66

Boman Index-0.05

Instability Index38.39

Aliphatic Index 90.00

Aromaticity 0.0833

Extinction Coeff. Reduced 41480.00

Extinction Coeff. Oxidized 41730.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6767.74

LogP -62.71

H-bond Donors 235.0

H-bond Acceptors 220.0

Rotatable Bonds 535.0

Heavy Atoms 1161.0

Ring Count 30.0

Amide Bonds 159.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0033528 VERIFIED: YES

Provenance & Taxonomy

OrganismBos taurus [Animal]

FamilyCathelicidin

Tax ID9913

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus (Gram-positive)