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MYP_036377
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Basic Information
Hill-Def 2a
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
40 amino acids
C179H294N62O48S6
Standard
Sequence
ATCDLLSPFKVGHAACAAHCIARGKRGGWCDKRAVCNCRK
Physicochemical Analysis
4275.03 Da
9.38
5.91
5.52
0.1477
-0.13
0.54
-0.10
49.30
61.25
0.0500
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1772.41
-20.83
70.0
62.0
140.0
295.0
6.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015736 VERIFIED: YES
Provenance & Taxonomy
Hermetia illucens [Animal]
Defensin
343691
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 8739
32 μM
IC50
PMID34985302 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34985302/
RECORD: Rec_0020037 VERIFIED: YES
Provenance & Taxonomy
Hermetia illucens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0027437 VERIFIED: YES
Provenance & Taxonomy
Hermetia illucens [Animal]
Defensin
343691
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Streptococcus suis CVCC606b
1.88 μM
MIC
PMID28935900 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28935900/
RECORD: Rec_0065473 VERIFIED: YES
Provenance & Taxonomy
Hermetia illucens [Animal]
Defensin
343691
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3-36
3-36
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans B59630
32 μM
IC50
PMID34985302 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34985302/
RECORD: Rec_0081868 VERIFIED: YES
Provenance & Taxonomy
Hermetia illucens [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Salmonella Typhimurium ATCC 14028, S.enteritidis CMCC50336
>128 μg/mL
MIC
PaperPurification and characterization of a novel antibacterial peptide from black soldier fly (Hermetia illucens) larvae
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