Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length478 amino acids

Chemical FormulaC2359H3722N590O687S25

DescriptionStandard

        MLPSVMVVFAILSCTRGKNPAVQVTLTDKWLQYVKHVGAGWIQDKLEHITFPDISGDVDILIGHVYYTLSGIRITKCDLPEPVLEFFQSTGLKTSIVGLNAALVGNWRTSFGIIHDGGSFDMAIFSVSLTSMVQLGRDPDGHLSITSIGCEPQVGNVAIQFHGGASFIFQPFVDHFKGKIVSVIQSNICPNVQTAIDDLESHLQAMSISYDVNEVLTVELPLTSPPVISGDDVNLGLKGEFYSIETHQEPPFVAQPFVLPKEPNYMMSVGLSEFMLNSASFGYFSAGNLQVLVNDSMIPPKSPVHLNTTSMGMFIPQLPKLYPDMLMNLQVYATEAPMLSLQMDVVEVGAQLGAKAFAIEPNGTQVPLFTLSVETRLSGKMWIVDEKLKANAMLDNITLTLASSEVGTFKMDALENVVKMGINLMGLPKLNALLGDGIFLPQMKQAQLVNPVLKLEKGFLVVSSDTKIVQTNRNFNTL
    

Molecular Weight52141.95 Da

Isoelectric Point (pI)5.06

Net Charge (pH 7.0)-14.62

Net Charge (pH 7.4) -15.49

Charge Density (pH 7.0) -0.0306

GRAVY Index0.23

Hydrophobic Moment 0.58

Boman Index0.21

Instability Index36.28

Aliphatic Index 102.49

Aromaticity 0.0795

Extinction Coeff. Reduced 35410.00

Extinction Coeff. Oxidized 35660.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0179289 VERIFIED: NO

Provenance & Taxonomy

OrganismNothobranchius pienaari [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria