‹ ›
MYP_036373
← PREVIOUS NEXT → BACK
Basic Information
Subtilosin A
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
35 amino acids
C152H234N38O46S3
Standard
Sequence
NKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG
Physicochemical Analysis
3425.91 Da
4.05
-2.27
-2.52
-0.0647
0.69
0.29
0.40
24.71
89.43
0.0857
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1292.63
-13.08
46.0
47.0
105.0
239.0
6.0
35.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0221832 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus subtilis
100 μM
MIC
PMID19633086 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19633086/
RECORD: Rec_0224617 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
1423
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
No specific N-terminal
No specific C-terminal
The N-terminal and C-terminal cyclized by a amide bond. Thioether bridges between Cys4 and Phe31,Cys7 and Thr28,Cys13 and Phe22.
Bio-Activity Profile
Antiviral Anti-HSV Replication inhibition
Herpes simplex virus type 2(HSV-2) | Vero cells
5.312 μM
EC50
Mammalian: 1.4 h; Yeast: 3 min; E. coli: >10 h
PaperAntiherpes simplex virus type 2 activity of the antimicrobial peptide subtilosin. | Quintana VM, Torres NI, Wachsman MB, Sinko PJ, Castilla V, Chikindas M. | J Appl Microbiol. 2014 Nov;117(5):1253-9. | DOI:10.1111/jam.12618 | PMID:25087911 PMID25087911 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25087911/
RECORD: Rec_0236050 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
Thioether bridges between Cys4 and Phe31,Cys7 and Thr28,Cys13 and Phe22
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
MICs between 1 and 12
PaperPubMed PMID: 3936839 | PubMed PMID: 15035610 PMID3936839;15035610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3936839/
RECORD: Rec_0240736 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
1423
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide (D-Thr28,D-Phe31) [Mixed]
not reported
not reported
The N-terminal and C-terminal cyclized by a amide bond. Thioether bridges between Cys4 and Phe31,Cys7 and Thr28,Cys13 and Phe22
Bio-Activity Profile
Antimicrobial Antiviral
herpes simplex virus type 2(HSV-2): inhibition of viral replication in Vero cells
18.2 μg/mL
EC50
PaperPubMed PMID: 25087911 PMID25087911 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25087911/
RECORD: Rec_0265866 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus carnosus
16 μM
MIC
PMID19633086 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19633086/
FIRST PREV 1 ... 4 5 6 7 8 ... 11 NEXT LAST
Showing 5 records on this page · Page 6 of 11