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MYP_036373
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Basic Information
Subtilosin A
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
35 amino acids
C152H234N38O46S3
Standard
Sequence
NKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG
Physicochemical Analysis
3425.91 Da
4.05
-2.27
-2.52
-0.0647
0.69
0.29
0.40
24.71
89.43
0.0857
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1292.63
-13.08
46.0
47.0
105.0
239.0
6.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0118264 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus subtilis
250 μM
MIC
PMID19633086 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19633086/
RECORD: Rec_0123493 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
Thioether bridges between Cys4 and Phe31,Cys7 and Thr28,Cys13 and Phe22
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Salmonella enterica Typhi ATCC 12048
PaperPubMed PMID: 3936839 | PubMed PMID: 15035610 PMID3936839;15035610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3936839/
RECORD: Rec_0128544 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Spermicidal
Streptococcus pyogenes
100 μM
MIC
PaperSubtilosin A, a new antibiotic peptide produced by Bacillus subtilis 168: isolation, structural analysis, and biogenesis.
RECORD: Rec_0164207 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
1423
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide (D-Thr28,D-Phe31) [Mixed]
not reported
not reported
The N-terminal and C-terminal cyclized by a amide bond. Thioether bridges between Cys4 and Phe31,Cys7 and Thr28,Cys13 and Phe22
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 25087911 PMID25087911 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25087911/
RECORD: Rec_0172161 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
Thioether bridges between Cys4 and Phe31,Cys7 and Thr28,Cys13 and Phe22
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus epidermidis ATCC 12228
PaperPubMed PMID: 3936839 | PubMed PMID: 15035610 PMID3936839;15035610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3936839/
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