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MYP_036373
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Basic Information
Subtilosin A
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
35 amino acids
C152H234N38O46S3
Standard
Sequence
NKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG
Physicochemical Analysis
3425.91 Da
4.05
-2.27
-2.52
-0.0647
0.69
0.29
0.40
24.71
89.43
0.0857
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1292.63
-13.08
46.0
47.0
105.0
239.0
6.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0035982 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus anthracis
16 μM
MIC
PMID19633086 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19633086/
RECORD: Rec_0039804 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
Thioether bridges between Cys4 and Phe31,Cys7 and Thr28,Cys13 and Phe22
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Streptococcus pyogenes ATCC 19615 and Shigella sonnei ATCC 25931
PaperPubMed PMID: 3936839 | PubMed PMID: 15035610 PMID3936839;15035610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3936839/
RECORD: Rec_0050260 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
1423
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide (D-Thr28,D-Phe31) [Mixed]
not reported
not reported
The N-terminal and C-terminal cyclized by a amide bond. Thioether bridges between Cys4 and Phe31,Cys7 and Thr28,Cys13 and Phe22
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 25087911 PMID25087911 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25087911/
RECORD: Rec_0051339 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Spermicidal
B. anthracis
16 μM
MIC
PaperSubtilosin A, a new antibiotic peptide produced by Bacillus subtilis 168: isolation, structural analysis, and biogenesis.
RECORD: Rec_0070579 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
Thioether bridges between Cys4 and Phe31,Cys7 and Thr28,Cys13 and Phe22
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
gingivalis ATCC 33277
PaperPubMed PMID: 3936839 | PubMed PMID: 15035610 PMID3936839;15035610 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3936839/
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