Peptide Database

Peptide NameSLAY-screened peptide P2888

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC46H67N15O19S

DescriptionStandard

        HSGRDSMFDD
    

Molecular Weight1166.18 Da

Isoelectric Point (pI)4.65

Net Charge (pH 7.0)-2.15

Net Charge (pH 7.4) -2.40

Charge Density (pH 7.0) -0.2146

GRAVY Index-1.55

Hydrophobic Moment 0.13

Boman Index-0.37

Instability Index40.60

Aliphatic Index 0.00

Aromaticity 0.1000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 568.16

LogP -7.97

H-bond Donors 20.0

H-bond Acceptors 19.0

Rotatable Bonds 38.0

Heavy Atoms 81.0

Ring Count 2.0

Amide Bonds 9.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0402457 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/