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MYP_036203
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Basic Information
Uperin-11
Antimicrobial
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Tachykinin peptide
Regulatory peptide ▸ Biological modulation
Standard
11 amino acids
C55H79N13O17S
Standard
Sequence
QADPNAFYGLM
Physicochemical Analysis
1226.36 Da
4.05
-1.24
-1.44
-0.1127
-0.15
0.22
0.22
23.29
53.64
0.1818
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
489.24
-3.97
15.0
17.0
36.0
86.0
3.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0044032 VERIFIED: NO
Provenance & Taxonomy
Uperoleia inundata [Animal]
Uperin
104953
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Amidation
Bio-Activity Profile
Neuropeptide Neuromodulator Vasoactive Vasodilator Receptor modulation
Mammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour
RECORD: Rec_0057335 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0065924 VERIFIED: YES
Provenance & Taxonomy
Uperoleia inundata [Animal]
Uperin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Smooth muscle contraction
PaperM.A. Apponyi et al. / Peptides 25 (2004) 1035-1054. Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance PMID15203252 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15203252/
RECORD: Rec_0358327 VERIFIED: NO
Provenance & Taxonomy
Uperoleia inundata [Animal]
Tachykinin
104953
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
Amidation
Bio-Activity Profile
Tachykinin Neuropeptide Neuromodulator
RECORD: Rec_0409182 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/