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MYP_036150
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Basic Information
Pituitary adenylate cyclase-activating polypeptide, PACAP-38
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Hormonal / Endocrine ▸ Hormone peptide
Metabolic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
38 amino acids
C207H330N68O54S
Standard
Sequence
HSDGIFTDSYSRYRKQMAVKKYLAAVLGRRYRQRFRNK
Physicochemical Analysis
4667.32 Da
11.03
8.84
8.57
0.2327
-1.14
0.68
-0.43
43.10
53.95
0.1579
5960.00
5960.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2071.79
-20.82
78.0
65.0
160.0
330.0
7.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0244901 VERIFIED: YES
Provenance & Taxonomy
Clarias gariepinus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Aeromonas salmonicida 4387/12
50 μM
MIC
PMID30481557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30481557/
RECORD: Rec_0261897 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Fish red blood cells:PACAP was not hemolytic for fish red blood cells at concentrations below 18
PaperPubMed PMID: 30481557 PMID30481557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30481557/
RECORD: Rec_0269389 VERIFIED: YES
Provenance & Taxonomy
Clarias gariepinus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Yersinia ruckeri 4319/03
50 μM
MIC
PMID30481557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30481557/
RECORD: Rec_0275686 VERIFIED: YES
Provenance & Taxonomy
Clarias gariepinus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Staphylococcus aureus
>300 μM
MIC
PaperEvidence for antimicrobial and anticancer activity of pituitary adenylate cyclase-activating polypeptide (PACAP) from North African catfish (Clarias gariepinus): Its potential use as novel therapeutic agent in fish and humans.
RECORD: Rec_0291728 VERIFIED: YES
Provenance & Taxonomy
Clarias gariepinus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli ATCC 8739
300 μM
MIC
PMID30481557 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30481557/
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