Peptide Database

Peptide NameDermaseptin-A3

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length75 amino acids

Chemical FormulaC365H602N98O121S4

DescriptionStandard

        MAFLKKSLFLVLLLGLISLSICEEEKRENEVEEEQEDDEQSELRRSLWSKIKEMAATAGKAALNAVTGMVNQGEQ
    

Molecular Weight8427.53 Da

Isoelectric Point (pI)4.59

Net Charge (pH 7.0)-6.48

Net Charge (pH 7.4) -6.74

Charge Density (pH 7.0) -0.0864

GRAVY Index-0.32

Hydrophobic Moment 0.59

Boman Index-0.04

Instability Index66.58

Aliphatic Index 97.60

Aromaticity 0.0400

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3597.30

LogP -34.23

H-bond Donors 123.0

H-bond Acceptors 119.0

Rotatable Bonds 302.0

Heavy Atoms 588.0

Ring Count 4.0

Amide Bonds 81.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0166909 VERIFIED: NO

Provenance & Taxonomy

OrganismAgalychnis annae [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Amphibian defense peptide Antibiotic Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic Non-ribosomal

TargetGram-negative bacteria; Gram-positive bacteria

MethodQualitative functional evidence