Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length448 amino acids

Chemical FormulaC2228H3504N554O646S18

DescriptionStandard

        MLPSVIAVLMLLSYTCGENPAIQVILTNKGLQYGKHTGTDWIQEILENVTLPDISGKFPIGRLGSVDYTLSGISITKVDLPEPSVEFYPNTTGLKSSMSGLSVALSGEWRTHYGIIHDGGTLDLALFSVSVMSIVELGKDANGHLSISSVTCTCTIGDVAIQFYGGASWIFRPFVPFFKGHIKGEIQSRICPKVEEVIVILEDHLQVMNVSFDVDQVLSLNLSLTGLPVIDASSLNLGLKGELYSIRTHKEPPFEAQSFTVPQQHSYMFSVGMSEFTLNSASYGCYSDGLLQATVNDSMIPPLSPVHLNTTSMGQFIPQLPKLFPGLLMSLTVYAREVPMFSLKPDAVKLDFQGTVKAFAILPNDTQAPLFTLNVVSNFVFWTFWAEKVKIDSASFMVYSPLVLILSLNHSVSVILGKGVDLPRMKSAQLVNSVLKVDEVSNSKKQRK
    

Molecular Weight48964.15 Da

Isoelectric Point (pI)5.81

Net Charge (pH 7.0)-6.64

Net Charge (pH 7.4) -7.53

Charge Density (pH 7.0) -0.0148

GRAVY Index0.24

Hydrophobic Moment 0.68

Boman Index0.20

Instability Index34.69

Aliphatic Index 103.46

Aromaticity 0.0893

Extinction Coeff. Reduced 45380.00

Extinction Coeff. Oxidized 45630.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0340079 VERIFIED: NO

Provenance & Taxonomy

OrganismMastacembelus armatus [Animal]

FamilyBPI

Tax ID205130

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence