‹ ›
MYP_035851
← PREVIOUS NEXT → BACK
Basic Information
Subtilosin A1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
35 amino acids
C154H238N38O45S3
Standard
Sequence
NKGCAICSIGAACLVDGPIPDFEIAGATGLFGLWG
Physicochemical Analysis
3437.96 Da
4.05
-2.27
-2.52
-0.0647
0.84
0.29
0.44
24.71
100.57
0.0857
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1272.40
-11.42
45.0
46.0
106.0
240.0
6.0
35.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0244389 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus cereus
6.4 μM
MIC
PMID19633086 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19633086/
RECORD: Rec_0253727 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0258883 VERIFIED: YES
Provenance & Taxonomy
Bacillus subtilis [Bacterium]
Bacteriocin
1423
Structure & Mods
thioether-constrained cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
Thioether bridges between Cys4 and Phe31,Cys7 and Thr28,Cys13 and Phe22
Bio-Activity Profile
Antimicrobial Antibacterial Hemolytic
rabbit blood agar
PaperPubMed PMID: 19633086 PMID19633086 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19633086/
RECORD: Rec_0272875 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Rabbit RBC
16 μM
Hemolysis
PMID19633086 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19633086/
RECORD: Rec_0273803 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
B.anthracis
256 μM
MIC
PaperIsolation of a variant of subtilosin A with hemolytic activity.
FIRST PREV 1 ... 3 4 5 6 NEXT LAST
Showing 5 records on this page · Page 5 of 6