Peptide Database

Peptide NameSLAY-screened peptide P862

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC114H168N28O29S

DescriptionStandard

        VATFVLCLYRTNIQSFLHWD
    

Molecular Weight2426.79 Da

Isoelectric Point (pI)6.72

Net Charge (pH 7.0)-0.19

Net Charge (pH 7.4) -0.47

Charge Density (pH 7.0) -0.0093

GRAVY Index0.58

Hydrophobic Moment 0.46

Boman Index0.27

Instability Index51.83

Aliphatic Index 112.00

Aromaticity 0.2000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 926.99

LogP -5.19

H-bond Donors 34.0

H-bond Acceptors 31.0

Rotatable Bonds 74.0

Heavy Atoms 172.0

Ring Count 6.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0351903 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/