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MYP_035759
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Basic Information
Casein beta [071-077]
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Standard
7 amino acids
C36H59N9O10
Standard
Sequence
PQNIPPL
Physicochemical Analysis
777.91 Da
5.96
-0.04
-0.10
-0.0059
-0.50
0.40
0.17
122.26
111.43
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
292.53
-2.02
8.0
10.0
20.0
55.0
3.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0059060 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory
Dipeptidyl peptidase IV
RECORD: Rec_0099733 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
DPP-IV inhibitory Antidiabetic
Dipeptidyl peptidase-IV (DPP-IV)
1500 μM
IC50
PaperIsolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from gouda-type cheese and its effect on plasma glucose in rats | Uenishi, H. et al. | DOI: 10.1016/j.idairyj.2011.08.002 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0103274 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
DPP-IV Inhibitory
DPP-IV
RECORD: Rec_0237741 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antidiabetic DPP-IV inhibitory
Dipeptidyl peptidase IV
1500.0
IC50
PaperUenishi H, Kabuki T, Seto Y, Serizawa A, Nakajima H. Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from Gouda type cheese and its effect on plasma glucose in rats. Int. Dairy. J. (2012) 22:24-30.