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MYP_035753
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Basic Information
Cyclotide mela-4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C134H213N35O39S6
Standard
Sequence
GKPICGETCFKGKCYTPGCTCSYPICKKN
Physicochemical Analysis
3130.73 Da
8.87
3.70
3.39
0.1275
-0.40
0.28
-0.03
3.06
26.90
0.1034
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1183.62
-13.65
46.0
49.0
99.0
214.0
6.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0023929 VERIFIED: YES
Provenance & Taxonomy
Melicytus latifolius [Animal]
Cyclotide
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
HeLa
18.73±1.82 μM
CC50
PaperPubMed PMID: 26322745 PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
RECORD: Rec_0074494 VERIFIED: NO
Provenance & Taxonomy
Melicytus latifolius [Plant]
Cyclotide
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperCyclotide mela-4 Evidence URLhttps://www.uniprot.org/uniprotkb/C0HK31/entry
RECORD: Rec_0110370 VERIFIED: YES
Provenance & Taxonomy
Melicytus latifolius [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Anti-Gram-negative
Escherichia coli
PaperPubMed PMID 26322745 | Ravipati et al. 2015 PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
RECORD: Rec_0127544 VERIFIED: YES
Provenance & Taxonomy
Melicytus latifolius [Animal]
Cyclotide
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 26322745 PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
RECORD: Rec_0194532 VERIFIED: YES
Provenance & Taxonomy
Melicytus latifolius [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic
Human cervical carcinoma HeLa
18.73±1.82 μM
IC50
PaperPubMed PMID 26322745 | Ravipati et al. 2015 PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
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