Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length126 amino acids

Chemical FormulaC624H1029N165O167S5

DescriptionStandard

        MCRLSPTKPMLLHAWLLLVALTTLTSGLNPGVKVKLTQKGLEYGRELGIASIQQKLKTIKLPDVSGSQKVNPIGKVSYSFTNMHIINVGLPQSAVSLVPGAGIKLSIGNAYLSLNGNWRVKYLKFM
    

Molecular Weight13675.18 Da

Isoelectric Point (pI)10.22

Net Charge (pH 7.0)11.66

Net Charge (pH 7.4) 11.30

Charge Density (pH 7.0) 0.0925

GRAVY Index0.20

Hydrophobic Moment 0.59

Boman Index0.16

Instability Index14.86

Aliphatic Index 114.44

Aromaticity 0.0635

Extinction Coeff. Reduced 16960.00

Extinction Coeff. Oxidized 16960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5300.21

LogP -45.73

H-bond Donors 183.0

H-bond Acceptors 186.0

Rotatable Bonds 458.0

Heavy Atoms 961.0

Ring Count 19.0

Amide Bonds 137.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0050598 VERIFIED: NO

Provenance & Taxonomy

OrganismPeriophthalmus magnuspinnatus [Bacterium]

FamilyBPI

Tax ID409849

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence