Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length474 amino acids

Chemical FormulaC2324H3680N602O688S15

DescriptionStandard

        PQCRGLNLQADTPSYKMKLWVPLVLLVCGATKCEEPGIKGRLTLKGLHYGWQVVLEEVQRRLSSLQIPDVSGSVSVPVLGAIYYSVSSLQIQELDLSHSDASFSSDTGLKVSVSDGRTRVTGYIEIRTVLFGTSSSLEVSVDGLSLSAVLGLTRDDAGRGALWNAGCSSSVGQVDLNFHGGSGWILSMFKGSMLGPIHDAFSQQLCPQFDRSVVQMETLLSSLPVTEPVDSVAALELSLVSPPLITEQNVDLLVRGQFVGLSQRWDVPYSPVEMDLPDAESRMLVLAVSQFSANSASYVHYKSGALRANITDDMIPKESPLRLNTKSFAAFAPELPNRFPGSPPLLLQLSAPSPPEVTCQTDLLTLGASLDIQLSALYPESPPAPAFQLQAVDELQHMMSFALKVIGFPLLNKKLQKVFPIPTPLVRLQSPTVRVFQGFLLVVSDLEIDPWTQYQKVSDVAWEIPKTHKPSPFL
    

Molecular Weight51542.67 Da

Isoelectric Point (pI)5.26

Net Charge (pH 7.0)-9.43

Net Charge (pH 7.4) -10.02

Charge Density (pH 7.0) -0.0199

GRAVY Index0.09

Hydrophobic Moment 0.63

Boman Index0.13

Instability Index50.52

Aliphatic Index 101.73

Aromaticity 0.0738

Extinction Coeff. Reduced 53400.00

Extinction Coeff. Oxidized 53775.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0093653 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus tropicalis [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence