Peptide Database

Peptide NameSLAY-screened peptide P1393

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC68H100N16O21S2

DescriptionStandard

        VPWCTTAPCPPSGEP
    

Molecular Weight1541.75 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.28

Net Charge (pH 7.4) -1.52

Charge Density (pH 7.0) -0.0855

GRAVY Index-0.27

Hydrophobic Moment 0.13

Boman Index0.21

Instability Index96.13

Aliphatic Index 26.00

Aromaticity 0.0667

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 540.55

LogP -5.77

H-bond Donors 18.0

H-bond Acceptors 22.0

Rotatable Bonds 35.0

Heavy Atoms 107.0

Ring Count 7.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0289832 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/