Peptide Database

Peptide NamePro-thyrotropin-releasing hormone

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length231 amino acids

Chemical FormulaC1173H1812N356O357S5

DescriptionStandard

        LPEAAQEEGAVTPDLPGLENVQVRPERRFLWKDLQRVRGDLGAALDSWITKRQHPGKREEEEKDIEAEERGDLGEGGAWRLHKRQHPGRRANQDKYSWADEEDSDWMPRSWLPDFFLDSWFSDVPQVKRQHPGRRSFPWMESDVTKRQHPGRRFIDPELQRSWEEKEGEGVLMPEKRQHPGKRALGHPCGPQGTCGQTGLLQLLGDLSRGQETLVKQSPQVEPWDKEPLEE
    

Molecular Weight26773.43 Da

Isoelectric Point (pI)5.52

Net Charge (pH 7.0)-7.56

Net Charge (pH 7.4) -8.23

Charge Density (pH 7.0) -0.0327

GRAVY Index-1.21

Hydrophobic Moment 0.67

Boman Index-0.26

Instability Index79.54

Aliphatic Index 57.40

Aromaticity 0.0736

Extinction Coeff. Reduced 56490.00

Extinction Coeff. Oxidized 56615.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0267708 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyTRH

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsPro55 Amidation; Pro87 Amidation; Gln130 Pyroglutamylation; Pro132 Amidation; Gln148 Pyroglutamylation; Pro150 Amidation; Pro180 Amidation

Bio-Activity Profile

Function

Hormone Neuropeptide