Peptide Database

Peptide NameDaratumumab

Function Ontology

Anticancer

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Standard StatusStandard

Sequence Length452 amino acids

Chemical FormulaC2204H3412N582O672S16

DescriptionStandard

        EVQLLESGGGLVQPGGSLRLSCAVSGFTFNSFAMSWVRQAPGKGLEWVSAISGSGGGTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYFCAKDKILWFGEPVFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
    

Molecular Weight49327.20 Da

Isoelectric Point (pI)8.37

Net Charge (pH 7.0)4.54

Net Charge (pH 7.4) 3.64

Charge Density (pH 7.0) 0.0101

GRAVY Index-0.33

Hydrophobic Moment 0.51

Boman Index0.03

Instability Index46.12

Aliphatic Index 71.48

Aromaticity 0.0951

Extinction Coeff. Reduced 74830.00

Extinction Coeff. Oxidized 75455.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0352949 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

FamilyMonoclonal antibody

Structure & Mods

Configcyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunomodulatory

Half-LifeIntravenous daratumumab has a terminal half life of 18 ± 9 days.6 Subcutaneous daratumumab has a half life of 20 days