Peptide Database

Peptide NameGnRH

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Reproductive neuropeptide

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC52H68N14O16S

DescriptionStandard

        EHWSYGMNPG
    

Molecular Weight1177.25 Da

Isoelectric Point (pI)5.24

Net Charge (pH 7.0)-1.08

Net Charge (pH 7.4) -1.30

Charge Density (pH 7.0) -0.1077

GRAVY Index-1.37

Hydrophobic Moment 0.32

Boman Index0.07

Instability Index-12.79

Aliphatic Index 0.00

Aromaticity 0.2000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 481.75

LogP -4.35

H-bond Donors 16.0

H-bond Acceptors 17.0

Rotatable Bonds 33.0

Heavy Atoms 83.0

Ring Count 5.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0006272 VERIFIED: YES

Provenance & Taxonomy

OrganismCoregonus clupeaformis [Animal]

FamilyGnRH

Tax ID59861

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamate

C-TermAmidation

Bio-Activity Profile

Function

Hormone Reproductive neuropeptide

RECORD: Rec_0351164 VERIFIED: YES

Provenance & Taxonomy

OrganismCoregonus clupeaformis [Animal]

FamilyGnRH

Tax ID59861

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

C-TermAmidation

Bio-Activity Profile

Function

-

Half-LifeMammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour

RECORD: Rec_0376555 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/