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MYP_035526
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Basic Information
Circulin-A
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
30 amino acids
C134H216N38O39S6
Standard
Sequence
GIPCGESCVWIPCISAALGCSCKNKVCYRN
Physicochemical Analysis
3175.77 Da
8.33
1.70
1.40
0.0567
0.42
0.26
0.16
26.56
78.00
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1223.77
-13.73
48.0
47.0
99.0
217.0
5.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0302998 VERIFIED: NO
Provenance & Taxonomy
Chassalia chartacea [Plant]
Cyclotide
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID22467870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467870/
RECORD: Rec_0313759 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
C. tropicalis
19.4 μM
MIC
PaperChemical structure of circulin A.
RECORD: Rec_0314529 VERIFIED: YES
Provenance & Taxonomy
Chassalia parvifolia [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Cytotoxic Antiviral Anti-HIV Anti-Gram-negative
Escherichia coli
500 μM
MIC
PaperPubMed PMID 10430870 | PubMed PMID 27208120 | Lactobacillus brevis L1055: >50 ?g/ml |Pediococcus dextrinicus DSM 20293: >50 ?g/ml|Staphylococcus aureus Newman: >50 ?g/ml|Salmonella typhimurium SL1344: >50 ?g/ml PMID10430870;27208120 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0329055 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20, 8-22, 13-27
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral Antifungal Hemolytic
PaperCyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID18008336;10430870;9878410;8920961 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0343067 VERIFIED: YES
Provenance & Taxonomy
Chassalia parvifolia [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Cytotoxic Antiviral Anti-HIV Anti-Gram-positive
Micrococcus luteus
500 μM
MIC
PaperPubMed PMID 10430870 | PubMed PMID 27208120 | Lactobacillus brevis L1055: >50 ?g/ml |Pediococcus dextrinicus DSM 20293: >50 ?g/ml|Staphylococcus aureus Newman: >50 ?g/ml|Salmonella typhimurium SL1344: >50 ?g/ml PMID10430870;27208120 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
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