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MYP_035526
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Basic Information
Circulin-A
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
30 amino acids
C134H216N38O39S6
Standard
Sequence
GIPCGESCVWIPCISAALGCSCKNKVCYRN
Physicochemical Analysis
3175.77 Da
8.33
1.70
1.40
0.0567
0.42
0.26
0.16
26.56
78.00
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1223.77
-13.73
48.0
47.0
99.0
217.0
5.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0284673 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Defensin
58431
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (C termini to N termini)
4-20, 8-22, 13-27
Disulfide bonds between Cys4 and Cys20, Cys8 and Cys22, Cys13 and Cys27.
Bio-Activity Profile
Antiviral Anti-HIV-1 Entry inhibition
HIV-1
0.04-0.26 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperCyclotides as natural anti-HIV agents. | Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. | Biopolymers. 2008;90(1):51-60. | DOI:10.1002/bip.20886 | PMID:18008336 PMID18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0286372 VERIFIED: YES
Provenance & Taxonomy
Chassalia parvifolia [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Cytotoxic Antiviral Anti-HIV
Candida tropicalis
19.4 μM
MIC
PaperPubMed PMID 10430870 | PubMed PMID 27208120 | Lactobacillus brevis L1055: >50 ?g/ml |Pediococcus dextrinicus DSM 20293: >50 ?g/ml|Staphylococcus aureus Newman: >50 ?g/ml|Salmonella typhimurium SL1344: >50 ?g/ml PMID10430870;27208120 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0287150 VERIFIED: YES
Provenance & Taxonomy
Chassalia parvifolia [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Cytotoxic Antiviral Anti-HIV
Candida albicans
500 μM
MIC
PaperPubMed PMID 10430870 | PubMed PMID 27208120 | Lactobacillus brevis L1055: >50 ?g/ml |Pediococcus dextrinicus DSM 20293: >50 ?g/ml|Staphylococcus aureus Newman: >50 ?g/ml|Salmonella typhimurium SL1344: >50 ?g/ml PMID10430870;27208120 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0289678 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
C. kefyr
18.6 μM
MIC
PMID10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0301114 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Cyclotide
Structure & Mods
cyclic cystine-knot peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond; sites not specified
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Staphylococcus aureus
PMID4288271;8920961;10430870;9878410 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/4288271/
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