‹ ›
MYP_035526
← PREVIOUS NEXT → BACK
Basic Information
Circulin-A
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
30 amino acids
C134H216N38O39S6
Standard
Sequence
GIPCGESCVWIPCISAALGCSCKNKVCYRN
Physicochemical Analysis
3175.77 Da
8.33
1.70
1.40
0.0567
0.42
0.26
0.16
26.56
78.00
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1223.77
-13.73
48.0
47.0
99.0
217.0
5.0
31.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0182013 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
C. tropicalis
19.4 μM
MIC
PMID10430870 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0196280 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20, 8-22, 13-27
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral Antifungal Hemolytic
blood type A human erythrocytes
1020 μM
EC50
PaperCyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID18008336;10430870;9878410;8920961 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0197244 VERIFIED: YES
Provenance & Taxonomy
Chassalia parvifolia [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
disulfide bond reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic Cytotoxic Antiviral Anti-HIV Anti-Gram-positive
Staphylococcus aureus
0.19 μM
MIC
PaperPubMed PMID 10430870 | PubMed PMID 27208120 | Lactobacillus brevis L1055: >50 ?g/ml |Pediococcus dextrinicus DSM 20293: >50 ?g/ml|Staphylococcus aureus Newman: >50 ?g/ml|Salmonella typhimurium SL1344: >50 ?g/ml PMID10430870;27208120 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10430870/
RECORD: Rec_0199799 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Staphylococcus aureus
0.19 μM
MIC
PaperChemical structure of circulin A.
RECORD: Rec_0206265 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiviral
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
FIRST PREV 1 ... 3 4 5 6 7 ... 10 NEXT LAST
Showing 5 records on this page · Page 5 of 10