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MYP_035526
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Basic Information
Circulin-A
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
30 amino acids
C134H216N38O39S6
Standard
Sequence
GIPCGESCVWIPCISAALGCSCKNKVCYRN
Physicochemical Analysis
3175.77 Da
8.33
1.70
1.40
0.0567
0.42
0.26
0.16
26.56
78.00
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1223.77
-13.73
48.0
47.0
99.0
217.0
5.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0053526 VERIFIED: YES
Provenance & Taxonomy
Chassalia parvifolia [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID8939880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8939880/
RECORD: Rec_0073382 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20, 8-22, 13-27
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral Antifungal
Proteus vulgaris
54.6 μM
MIC
PaperCyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID18008336;10430870;9878410;8920961 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0078468 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Candida albicans
>500 μM
MIC
PaperChemical structure of circulin A.
RECORD: Rec_0086812 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20, 8-22, 13-27
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral Antifungal
Candida tropicalis
19.4 μM
MIC
PaperCyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID18008336;10430870;9878410;8920961 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0098778 VERIFIED: NO
Provenance & Taxonomy
Chassalia parviflora [Plant]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
Staphylococcus aureus
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