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MYP_035486
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Basic Information
Brevinin-2CE
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
37 amino acids
C164H286N46O47S2
Standard
Sequence
GLLSVFKGVLKTAGKNVAKNVAGSLLDQLKCKISGGC
Physicochemical Analysis
3718.43 Da
9.79
4.74
4.49
0.1280
0.39
0.60
0.15
-2.47
113.24
0.0270
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1514.53
-16.63
54.0
54.0
132.0
259.0
1.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0051104 VERIFIED: YES
Provenance & Taxonomy
Rana chensinensis [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
31-37
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
73.0 μM
HC50
PaperJ. Zhao et al. / Zoological Science 28 (2011) 112-117. Molecular Cloning of Novel Antimicrobial Peptide Genes from the Skin of the Chinese Brown Frog, Rana chensinensis Evidence URLhttps://www.uniprot.org/uniprotkb/F1AEM1/entry
RECORD: Rec_0099964 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0177757 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID24474334 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24474334/
RECORD: Rec_0183772 VERIFIED: YES
Provenance & Taxonomy
Rana chensinensis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0186050 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID24474334 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24474334/
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