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MYP_035482
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Basic Information
Unnamed
Antimicrobial
Enzyme modulation ▸ Enzyme inhibition ▸ Inhibition of ileum cells contraction
Enzyme modulation ▸ Enzyme inhibition ▸ Inhibition of vas deferens cells contraction
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Neurological / Signaling ▸ Analgesic/antinociceptive activity
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Standard
7 amino acids
C44H61N9O11S2
Standard
Sequence
YMFHLMD
Physicochemical Analysis
956.14 Da
5.33
-1.15
-1.41
-0.1642
0.34
0.35
0.36
71.34
55.71
0.2857
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
324.13
0.49
11.0
13.0
29.0
66.0
3.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0288717 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
deltorphin
8395
Structure & Mods
linear peptide [Linear]
D-residue-containing modified peptide [Mixed]
Amidation
2:D-methionine
Bio-Activity Profile
Neuropeptide Neuromodulator Receptor modulation
Mammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for deltorphin A (Phyllomedusa sauvagei): PMID 9949868 PMID9949868 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9949868/
RECORD: Rec_0310335 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa [Animal]
Opioid
8392
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Opioid Analgesic Neuromodulator
PMID9949868 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9949868/
RECORD: Rec_0374689 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa sauvagii [Animal]
Deltorphin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Inhibition of ileum cells contraction Inhibition of vas deferens cells contraction Mu-receptor affinity Delta-receptor affinity Antinociceptive
PaperK. Richter et al. / PNAS 87 (1990) 4836-4839. cDNAs encoding [D-Ala2]deltorphin precursors from skin of Phyllomedusa bicolor also contain genetic information for three dermorphin-related opioid peptides Evidence URLhttps://www.uniprot.org/uniprotkb/P05422/entry
RECORD: Rec_0411802 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
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