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MYP_035455
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Basic Information
cycloCP-11
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
15 amino acids
C102H148N28O16S2
Standard
Sequence
ICLKKWPWWPWRRCK
Physicochemical Analysis
2086.57 Da
10.33
4.74
4.50
0.3158
-0.95
0.46
-0.20
50.86
52.00
0.2667
22000.00
22125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
718.16
0.96
29.0
23.0
61.0
148.0
10.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0283495 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-15
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis
64 μg/mL
MIC
PMID14640680 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14640680/
RECORD: Rec_0284565 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Indolicidin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
2-14
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
16 μg/mL
MIC
Trypsin: Half-life is 4 min
PaperRozek A, Powers JP, Friedrich CL, Hancock RE. Structure-based design of an indolicidin peptide analogue with increased protease stability. Biochemistry. 2003 Dec 9;42(48):14130-8. PMID:14640680 https://pubmed.ncbi.nlm.nih.gov/14640680/ PMID14640680 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14640680/
RECORD: Rec_0325181 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-15
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Salmonella typhimurium
64 μg/mL
MIC
PMID14640680 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14640680/
RECORD: Rec_0400325 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-15
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
16 μg/mL
MIC
PMID14640680 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14640680/
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