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MYP_035430
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Basic Information
Hydramacin-1 (Hm-1; annelida, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
60 amino acids
C300H471N91O88S8
Standard
Sequence
QIVDCWETWSRCTKWSQGGTGTLWKSCNDRCKELGRKRGQCEEKPSRCPLSKKAWTCICY
Physicochemical Analysis
7017.03 Da
9.05
5.69
5.35
0.0948
-0.95
0.64
-0.26
39.21
39.00
0.1000
28990.00
29490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2951.92
-32.75
115.0
102.0
233.0
487.0
13.0
63.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0199176 VERIFIED: YES
Provenance & Taxonomy
Hydra magnipapillata [other]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
It is the founding member of the macin family. Chemical modification: It consists of 4 conserved disulfide bonds: C1-C6, C2-C5, C3-C7, and C4-C8
Bio-Activity Profile
Antimicrobial
A. baumannii ATCC 19606 (LD90 1.8 uM), C. freundii NCTC 9750
PaperHydramacin-1, structure and antibacterial activity of a protein from the basal metazoan Hydra
RECORD: Rec_0204258 VERIFIED: YES
Provenance & Taxonomy
Hydra magnipapillata [Animal]
Macin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Burkholderia cepacia LMG 16654
14.3 μM
MBC
PMID19019828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19019828/
RECORD: Rec_0206464 VERIFIED: YES
Provenance & Taxonomy
Hydra vulgaris [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Burkholderia cepacia ATCC 17759
14.3 μM
MBC
PaperPubMed PMID: 19013190 | PubMed PMID: 19019828 PMID19013190;19019828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19013190/
RECORD: Rec_0211820 VERIFIED: YES
Provenance & Taxonomy
Hydra magnipapillata [Animal]
Macin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa NCTC 11446
14.3 μM
MBC
PMID19019828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19019828/
RECORD: Rec_0213109 VERIFIED: YES
Provenance & Taxonomy
Hydra magnipapillata [Animal]
Macin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella oxytoca ATCC 13182
0.9 μM
MBC
PMID19019828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19019828/
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