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MYP_035430
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Basic Information
Hydramacin-1 (Hm-1; annelida, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
60 amino acids
C300H471N91O88S8
Standard
Sequence
QIVDCWETWSRCTKWSQGGTGTLWKSCNDRCKELGRKRGQCEEKPSRCPLSKKAWTCICY
Physicochemical Analysis
7017.03 Da
9.05
5.69
5.35
0.0948
-0.95
0.64
-0.26
39.21
39.00
0.1000
28990.00
29490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2951.92
-32.75
115.0
102.0
233.0
487.0
13.0
63.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0166542 VERIFIED: YES
Provenance & Taxonomy
Hydra magnipapillata [Animal]
Macin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella oxytoca ESBL 37
3.6 μM
MBC
PMID19019828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19019828/
RECORD: Rec_0172331 VERIFIED: YES
Provenance & Taxonomy
Hydra vulgaris [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
vulgaris ATCC 13315
14.3 μM
MBC
PaperPubMed PMID: 19013190 | PubMed PMID: 19019828 PMID19013190;19019828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19013190/
RECORD: Rec_0185761 VERIFIED: YES
Provenance & Taxonomy
Hydra magnipapillata [Animal]
Macin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella oxytoca ESBL 33
7.1 μM
MBC
PMID19019828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19019828/
RECORD: Rec_0189373 VERIFIED: YES
Provenance & Taxonomy
Hydra magnipapillata [Animal]
Macin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis ATCC 51299
14.3 μM
MBC
PMID19019828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19019828/
RECORD: Rec_0198639 VERIFIED: YES
Provenance & Taxonomy
Hydra vulgaris [Animal]
macin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
5-48; 12-41; 27-57; 31-59
Bio-Activity Profile
Antimicrobial macin family Antibacterial Host defense
PaperPDB 2K35 structural record; NMR; chain A; residues 1-60
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