Peptide Database

Peptide NameSLAY-screened peptide P4477

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC111H168N28O31S2

DescriptionStandard

        LSMFRCPDTYPDHFLELTLR
    

Molecular Weight2454.82 Da

Isoelectric Point (pI)5.38

Net Charge (pH 7.0)-1.16

Net Charge (pH 7.4) -1.43

Charge Density (pH 7.0) -0.0579

GRAVY Index-0.21

Hydrophobic Moment 0.52

Boman Index-0.01

Instability Index14.69

Aliphatic Index 78.00

Aromaticity 0.1500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 943.94

LogP -6.02

H-bond Donors 34.0

H-bond Acceptors 33.0

Rotatable Bonds 75.0

Heavy Atoms 172.0

Ring Count 6.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0380709 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/