Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length184 amino acids

Chemical FormulaC929H1457N239O256S11

DescriptionStandard

        MSSRSPFTGSWVSQWTACGKGEFFRLAHRRPPPFAPPALTLPTDHNHMVYLGISEYLFNTAGLVYQEAGVLNLTLSDDMVAKMFPDMKMQLLIWAPSPPNVAVCPTGLDLTFSLDTQAVAVLPDSSLAPLFLLEMNMNISVDIRARSNRLVGELKLDKLLLKLKHSDIDHFPVSLRPLMAPSFL
    

Molecular Weight20422.67 Da

Isoelectric Point (pI)6.50

Net Charge (pH 7.0)-1.07

Net Charge (pH 7.4) -1.60

Charge Density (pH 7.0) -0.0058

GRAVY Index0.15

Hydrophobic Moment 0.57

Boman Index0.15

Instability Index51.81

Aliphatic Index 98.59

Aromaticity 0.0870

Extinction Coeff. Reduced 20970.00

Extinction Coeff. Oxidized 21095.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7744.53

LogP -82.97

H-bond Donors 264.0

H-bond Acceptors 271.0

Rotatable Bonds 649.0

Heavy Atoms 1435.0

Ring Count 41.0

Amide Bonds 194.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0174498 VERIFIED: NO

Provenance & Taxonomy

OrganismEschrichtius robustus [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence