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MYP_035338
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Basic Information
hepcidin 20
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Regulatory peptide ▸ Biological modulation
Standard
20 amino acids
C85H143N27O23S9
Standard
Sequence
ICIFCCGCCHRSKCGMCCKT
Physicochemical Analysis
2199.80 Da
8.53
2.77
2.39
0.1383
0.80
0.15
0.09
47.77
39.00
0.0500
0.00
500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
799.30
-9.74
37.0
36.0
72.0
144.0
2.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0331974 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 40.0%, T 30.0%, C 30.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0339877 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli ML35p
PMID11113131 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11113131/
RECORD: Rec_0357893 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Staphylococcus epidermidis
3.12, 6.25, 12.5, 25, 50 μM
Crystal violet assay; Total countable CFUs
RECORD: Rec_0362315 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Bacillus subtilis
2.69 μg/mL
MIC
PaperHepcidin, a urinary antimicrobial peptide synthesized in the liver.
RECORD: Rec_0404130 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Aspergillus fumigatus
PaperPubMed PMID: 11113131 | PubMed PMID: 12138110 | PubMed PMID: 11034317 PMID11113131;12138110;11034317 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11113131/
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