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MYP_035338
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Basic Information
hepcidin 20
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Regulatory peptide ▸ Biological modulation
Standard
20 amino acids
C85H143N27O23S9
Standard
Sequence
ICIFCCGCCHRSKCGMCCKT
Physicochemical Analysis
2199.80 Da
8.53
2.77
2.39
0.1383
0.80
0.15
0.09
47.77
39.00
0.0500
0.00
500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
799.30
-9.74
37.0
36.0
72.0
144.0
2.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0216468 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID10942757 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10942757/
RECORD: Rec_0234956 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Aspergillus niger
PaperPubMed PMID: 11113131 | PubMed PMID: 12138110 | PubMed PMID: 11034317 PMID11113131;12138110;11034317 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11113131/
RECORD: Rec_0239904 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
group B Streptococcus
PaperPubMed PMID: 11113131 | PubMed PMID: 12138110 | PubMed PMID: 11034317 PMID11113131;12138110;11034317 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11113131/
RECORD: Rec_0241564 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
disulfide-constrained peptide [Cyclic]
canonical L-amino-acid peptide [L]
2-18; 5-8; 6-14; 9-17
Bio-Activity Profile
Antimicrobial Hormone Endocrine Receptor modulation Immunomodulatory ACE inhibitory
Mammalian: 20 hour; Yeast: 30 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Hepcidin-20 (Homo sapiens): PMID 19553669 PMID19553669 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19553669/
RECORD: Rec_0255860 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
PaperPubMed PMID: 11113131 | PubMed PMID: 12138110 | PubMed PMID: 11034317 PMID11113131;12138110;11034317 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11113131/
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