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MYP_035338
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Basic Information
hepcidin 20
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Regulatory peptide ▸ Biological modulation
Standard
20 amino acids
C85H143N27O23S9
Standard
Sequence
ICIFCCGCCHRSKCGMCCKT
Physicochemical Analysis
2199.80 Da
8.53
2.77
2.39
0.1383
0.80
0.15
0.09
47.77
39.00
0.0500
0.00
500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
799.30
-9.74
37.0
36.0
72.0
144.0
2.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006682 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Staphylococcus epidermidis ATCC 35984
3.12, 6.25, 25, 50 μM
Crystal violet assay; Total countable CFUs
RECORD: Rec_0014958 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Staphylococcus epidermidis ATCC 35984
100 μM
Total countable CFUs
RECORD: Rec_0020881 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Staphylococcus aureus
5.38 μg/mL
MIC
PaperHepcidin, a urinary antimicrobial peptide synthesized in the liver.
RECORD: Rec_0022108 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
hepcidin family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-18; 5-8; 6-14; 9-17
Bio-Activity Profile
Antimicrobial hepcidin family Antibacterial Antifungal Hormone Host defense
PaperPDB 1M4E structural record; NMR; chain A; residues 1-20
RECORD: Rec_0056115 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hepcidin
9606
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
PaperPubMed PMID: 11113131 | PubMed PMID: 12138110 | PubMed PMID: 11034317 PMID11113131;12138110;11034317 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11113131/
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