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MYP_035337
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
37 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
IEEIQKKIEEIQKKIEEIQKKIEEIQKKIEEIQKKXK
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0043405 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 36
Bio-Activity Profile
Antiviral
MERS-CoV PsV
PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0044044 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 36
Bio-Activity Profile
Hemolytic
Madin-Darby canine kidney cells
>100 μM
Cytotoxicity
PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0156714 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 36
Bio-Activity Profile
Antiviral
MERS-CoV
PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0180726 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 36
Bio-Activity Profile
Antiviral
Human Influenza A Virus H1N1
3.03
EC50
PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
RECORD: Rec_0182695 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
X= β-Ala
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperDe Novo Design of alpha-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. J Med Chem. 2018 Oct 11;61(19):8734-8745. doi: 10.1021/acs.jmedchem.8b00890. PMID: 30192544. PMID30192544 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30192544/
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