Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length477 amino acids

Chemical FormulaC2364H3789N669O656S15

DescriptionStandard

        MQLCLLLLLSALATTTNPGITARLTPRALEFGRQLGLQLLQSRLQKDHELNLKGSYHSPLLGTLTYTVPRIHVHELQMNDSTVDFVEDVGVRLRVQHGRVRLSADWGAQLGAIQDKGTAELRTHDLAVGLVLGVGVDGSGRPMVWSAACDARATNLHVEFHQGHSWFYNLLAPLLQRVLRQELNKQLCPELHRAIGQLEAALKDMRVSSQLDPFAAIDYSLLGRPLIMVEHGDAAIKGEFFRVGKCQQSPCSPLPAALPVPLPEALPVVHEPMLLLAVTDFVANSAAFTYFTAGALRRNVSGDMLPQRFPLQLRTKSLGLFSPQLQERYPDQPMELQLWARQQPLLSCRPDALHGTLFGSAEAFVVLPNATRIPAFLLNIDANVTGKPSISGNRLRGTVKLTGLRVTQVKSHVGPVEVTRLETLLKFGLWLFGVPWANKRLQAGIPLPTPHGLRLLNPQLSLQEGFMLIATDLQHQT
    

Molecular Weight52559.44 Da

Isoelectric Point (pI)9.16

Net Charge (pH 7.0)7.89

Net Charge (pH 7.4) 6.71

Charge Density (pH 7.0) 0.0165

GRAVY Index0.02

Hydrophobic Moment 0.77

Boman Index0.09

Instability Index41.39

Aliphatic Index 105.91

Aromaticity 0.0629

Extinction Coeff. Reduced 41940.00

Extinction Coeff. Oxidized 42315.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0054192 VERIFIED: NO

Provenance & Taxonomy

OrganismPatagioenas fasciata monilis [Animal]

FamilyBPI/LBP

Tax ID372326

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria